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Thread: CCR5 Mutation in Indigenous Populations in Brazil

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    Post HIV resitence in Brazilian Germans

    Abstract:


    Abstract. We investigated the occurrence of the CCR5(32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had (32/(32). German descendents were 11% heterozygous and l% (32/(32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.

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    Senior Member Esther_Helena's Avatar
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    Post Re: HIV resitence in Brazilian Germans

    I'm kinda lost as to what you just said... Anyways, my history teacher mentioned something. The topic was Athens..(Middle Ages work too). He mentioned that the decendants of the people, who survived the bubonic plague had an immunity to HIV.
    mtDNA - H_7_a (ftDNA) H_7_a_1 (23andme)
    AbDNA - 100% Eur. 23andme: 99.99% Eur., .01% Af.
    23andme: 99.73% European, .27% African
    23andme V3 update awaiting use, got a kit for mom too.

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    Post CCR5 Mutation in Indigenous Populations in Brazil

    Absence of the (ccr5 mutation in indigenous populations of the Brazilian Amazon


    A.P.M. Leboute, M.W.P. de Carvalho, A.L. Simões

    A1 Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900 - Monte Alegre, Ribeirão Preto, SP, Brasil, CEP 14049-900
    A2 Departamento de Genética, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cid. Universitaria, Recife, PE, Brasil, CEP 50670-901


    Abstract:


    Abstract. Carriers of the (ccr5 allele, which contains a deletion of 32 bases in relation to the normal allele of the #-chemokine receptor gene (CCR5), have increased resistance to HIV-1 infection. The higher frequency of this mutation in Europeans than in Blacks and Asians, has generated interest in determining its distribution in other populations. The population of this study involved 300 Amerindians from four Brazilian Amazon tribes (Tikuna, Baniwa, Kashinawa, and Kanamari). All of the individuals were homozygous for the normal allele, which corroborates the hypothesis that the (ccr5 allele has a European origin, and that its occurrence in urban populations in South America is the result of immigration.

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