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Thread: X-Chromosomal Lineages in Europe Reveal Middle Eastern and Asiatic Contacts

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    Exclamation X-Chromosomal Lineages in Europe Reveal Middle Eastern and Asiatic Contacts

    Within Europe, classical genetic markers, nuclear autosomal and Y-chromosome DNA polymorphisms display an east-west frequency gradient. This has been taken as evidence for the westward migration of Neolithic farmers from the Middle East. In contrast, most studies of mtDNA variation in Europe and the Middle East have not revealed clinal distributions. Here we report an analysis of dys44 haplotypes, consisting of 35 polymorphisms on an 8 kb segment of the dystrophin gene on Xp21, in a sample of 1203 Eurasian chromosomes.

    Our results do not show a significant genetic structure in Europe, though when Middle Eastern samples are included a very low but significant genetic structure, rooted in Middle Eastern heterogeneity, is observed. This structure was not correlated to either geography or language, indicating that neither of these factors are a barrier to gene flow within Europe and/or the Middle East. Spatial autocorrelation analysis did not show clinal variation from the Middle East to Europe, though an underlying and ancient east-west cline across the Eurasian continent was detected.

    Clines provide a strong signal of ancient major population migration(s), and we suggest that the observed cline likely resulted from an ancient, bifurcating migration out of Africa that influenced the colonizing of Europe, Asia and the Americas. Our study reveals that, in addition to settlements from the Near East, Europe has been influenced by other major population movements, such as expansion(s) from Asia, as well as by recent gene flow from within Europe and the Middle East.

    Source: European Journal of Human Genetics (2004) 12, 301-311.

    ''In conclusion, this study suggests that the demographic history of Europe, in addition to Neolithic expansions from the Near East, has been influenced by other major population movements, such as population expansions from Asia, and further reshaped by intracontinental gene flow. A large-scale survey of Eurasian X-chromosomal diversity would greatly assist in the identification of a number of migrations that have shaped the contemporary European gene pool, and provide more clues to understand the ancient routes and migrations of modern humans within Eurasia.''

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    Re: Middle Eastern and Asiatic contacts

    Quote Originally Posted by Euclides

    Human X-chromosomal lineages in Europe reveal Middle Eastern and Asiatic contacts
    Great article! Nice to see that scientists are also doing research on the X chromosome and not just restricting themselves to the Y chromosome and mitochondrial DNA.

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