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Thread: Australians and Melanesians

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    Post Australians and Melanesians

    “Independent histories of human Y chromosomes from Melanesia and Australia”
    Kayser, M., Brauer, S., Weiss, G., Schiefenhšvel, W., Underhill, P. A. and Stoneking, M.
    American Journal of Human Genetics, 2001, volume 68, number 1, pages 173-190

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    Grin American Doctors Treating Africans as "Subhuman Guinea Pigs"

    S. Africa Attacks U.S. Over AIDS Drug

    Fri Dec 17, 2:10 PM ET

    By ALEXANDRA ZAVIS, Associated Press Writer

    JOHANNESBURG, South Africa - President Thabo Mbeki's ruling party published a stinging attack Friday on top U.S. health officials, accusing them of treating Africans like "guinea pigs" and lying to promote a key AIDS (news - web sites) drug.

    The criticism reinforces fears of doctors and activists that new questions about the testing of nevirapine could halt use of the drug that's credited with protecting thousands of African babies from catching HIV (news - web sites) from their mothers.

    The article, published in the online journal ANC Today, was responding to Associated Press reports this week that U.S. health officials withheld criticism of a nevirapine study before President Bush (news - web sites) launched a 2002 plan to distribute the drug in Africa.

    Documents obtained by AP show Dr. Edmund C. Tramont, chief of the National Institutes of Health (news - web sites)'s AIDS division, rewrote an NIH report to omit negative conclusions about the way a U.S.-funded drug trial was conducted in Uganda, and later ordered the research to continue over the objections of his staff. Tramont's staff worried about record-keeping problems, violations of federal patient safeguards and other issues at the Uganda research site.

    "Dr. Tramont was happy that the peoples of Africa should be used as guinea pigs, given a drug he knew very well should not be prescribed," the article said. "In other words, they entered into a conspiracy with a pharmaceutical company to tell lies to promote the sales of nevirapine in Africa, with absolutely no consideration of the health impact of those lies on the lives of millions of Africans."

    Smuts Ngonyama, an African National Congress (news - web sites) spokesman and editor of the journal, said the article was an opinion piece by a member and didn't reflect official party policy. He wouldn't identify the author.

    In the United States, the Rev. Jesse Jackson (news - web sites) called for a U.S. congressional investigation and demanded nevirapine no longer be distributed in Africa.

    "This was not a thoughtful and reasonable decision, but a crime against humanity," Jackson said Thursday in Chicago. "Research standards and drug quality that are unacceptable in the U.S. and other Western countries must never be pushed onto Africa."

    Dr. H. Clifford Lane, the NIH's No. 2 infectious disease specialist and one of Tramont's bosses, has said an internal review cleared Tramont of scientific misconduct.

    He said Tramont changed the report because he was more experienced than his safety experts and had an "honest difference of opinion." Tramont has also argued that Africans in the midst of an AIDS crisis deserved some leniency in meeting tough U.S. safety standards.

    Some 70 percent of the 45 million people worldwide infected with HIV live in sub-Saharan Africa.

    Studies have shown that a single dose of nevirapine to an infected woman during labor and another dose to her newborn can reduce the chances of HIV transmission by up to 50 percent. Nevirapine is also used in combination with other drugs to prolong the lives of AIDS patients.

    Subsequent research has confirmed the safety and efficacy of nevirapine in protecting newborns, according to the World Health Organization (news - web sites). But there's evidence women who receive a single dose during pregnancy can develop resistance to the drug that can compromise their future AIDS treatment.

    WHO recommends nevirapine be used in combination with other drugs where possible — a strategy that has reduced transmission to less than 1 percent in wealthier countries. But it says resistance concerns must be weighed against the practicality of administering a single dose of nevirapine in impoverished African countries.

    Doctors and AIDS activists in Africa are worried governments may now halt use of single-dose nevirapine before alternatives are available.

    "It's an issue affecting people's lives," said Dr. Saul Onyango, who was involved in the testing in Uganda. "A lot of damage has already been done."

    Activists in South Africa accused the Health Department and ruling party officials this week of putting out misleading statements that could frighten patients off their treatment.

    "There is to date not a single life-threatening adverse event associated with this regimen which is widely used in the developing world," the Treatment Action Campaign said.

    In July, South Africa's Medicines Control Council recommended that nevirapine only be used in combination with other drugs because of the resistance concerns.

    The Health Department this week welcomed U.S. concerns about the quality of nevirapine research in Uganda, saying it supported its cautious attitude to the drug.

    Until this year, Mbeki's government refused to provide anti-retroviral drugs through the public health system, citing safety and cost concerns. A coalition of doctors and AIDS activists won a 2002 Constitutional Court order requiring the government to immediately expand a pilot nevirapine program to all infected pregnant women.

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    aka Wehrmacht

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    Yeah, why bother treating the niggers at all. Let them infect each other and die.

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