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Thread: Linkage Analysis In Psychiatric Disorders

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    Post Linkage Analysis In Psychiatric Disorders

    Annual Review of Genomics and Human Genetics


    September 2002, Vol. 3, pp. 371-413
    (doi:10.1146/annurev.genom.3.022502.103141)
    First published online as a Review in Advance on June 4, 2002
    LINKAGE ANALYSIS IN PSYCHIATRIC DISORDERS: The Emerging Picture

    Pamela Sklar

    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital and Whitehead Institute Center for Genome Research, Cambridge, Massachusetts 02139;






    Abstract Gene finding in genetically complex diseases has been difficult as a result of many factors that have diagnostic and methodologic considerations. For bipolar disorder and schizophrenia, numerous family, twin, and adoption studies have identified a strong genetic component to these behavioral psychiatric disorders. Despite difficulties that include diagnostic differences between sample populations and the lack of statistical significance in many individual studies, several promising patterns have emerged, suggesting that true susceptibility loci for schizophrenia and bipolar disorder may have been identified. In this review, the genetic epidemiology of these disorders is covered as well as linkage findings on chromosomes 4, 12, 13, 18, 21, and 22 in bipolar disorder and on chromosomes 1, 6, 8, 10, 13, 15, and 22 in schizophrenia. The sequencing of the human genome and identification of numerous single nucleotide polymorphisms (SNP) should substantially enhance the ability of investigators to identify disease-causing genes in these areas of the genome.

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    Post Re: Linkage Analysis In Psychiatric Disorders

    Well, it seems that is still much to do for the scientific analysis of mental disorders.

    Interesting was the claim that Schizophrenes are more often heavy smokers.
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    Post Re: Linkage Analysis In Psychiatric Disorders

    I've never had any doubts about the inheritability of mental diseases, especially schziophrenia. There are many studies readily available showing the disease going back generations, in varying degrees. The only question in my mind is how much the environment factors into the severity of the symptoms displayed and how it can be minimized or cured, if at all. The side-effects from drugs that schizophrenics receive are often more disturbing that the symptoms of the disease itself. What would you rather be? A raving lunatic or a drooling zombie? Nice choice.

    I like the mentally ill, though, they are so much more interesting.

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    Post Re: Linkage Analysis In Psychiatric Disorders

    Quote Originally Posted by Sigrun Christianson
    I've never had any doubts about the inheritability of mental diseases, especially schziophrenia. There are many studies readily available showing the disease going back generations, in varying degrees. The only question in my mind is how much the environment factors into the severity of the symptoms displayed and how it can be minimized or cured, if at all. The side-effects from drugs that schizophrenics receive are often more disturbing that the symptoms of the disease itself. What would you rather be? A raving lunatic or a drooling zombie? Nice choice.

    I like the mentally ill, though, they are so much more interesting.
    It makes me wonder how genes of this type have become so widespread - is it because modern society has allowed such unsocial types to survive into adulthood... or is it that perhaps being heterozygous for schizophrenia genes gives some advantage - perhaps a Schizothymic mind as has been discussed on other forums.
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