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Thread: Selective Serotonin-Reuptake Inhibitors (SSRIs): An Update

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    Post Selective Serotonin-Reuptake Inhibitors (SSRIs): An Update

    Selective serotonin-reuptake inhibitors: an update.

    Masand PS, Gupta S.


    Psychiatric Consultation Service, Regional Psychopharmacology Consultation and Training Program, SUNY Health Science Center at Syracuse, NY 13210, USA.

    Selective serotonin-reuptake inhibitors (SSRIs), including fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram, represent an important advance in the pharmacotherapy of mood and other disorders. They are chemically unrelated to tricyclic, heterocyclic, and other first-generation antidepressants. SSRIs are the treatment of choice for many indications, including major depression, dysthymia, panic disorder, obsessive-compulsive disorder, eating disorders, and premenstrual dysphoric disorder, because of their efficacy, good side-effect profile, tolerability, and safety in overdose, as well as patient compliance. A review of the literature was conducted using Medline and the terms "SSRIs," "fluoxetine," "sertraline," "paroxetine," "fluvoxamine," and "citalopram." Articles were limited to those published in English within the last 15 years. The search revealed that indications for antidepressants include unipolar depression, dysthymia, bipolar depression, treatment-resistant depression, depression in the medically ill, panic disorder, obsessive-compulsive disorder, eating disorders, social phobia, and premenstrual dysphoric disorder. One SSRI, fluoxetine, has demonstrated safety in pregnancy. Side effects of SSRIs include gastrointestinal disturbances, headache, sedation, insomnia, activation, weight gain, impaired memory, excessive perspiration, paresthesia, and sexual dysfunction.

    PMID: 10471245 [PubMed - indexed for MEDLINE]

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    Post Insight on Fluoxetine A Multi-disciplinary assessment of psychotropic medication

    http://www-personal.umich.edu/~kruger/

    Read the article on the personal homepage of Daniel J. Kruger, Ph.D.

    His critique of the pseuoscientific Postmodernists is also just wonderful.

    Evolutionary Psychology is great! It is definitely of anthropological value.

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