The mitochondrial haplogroup M, first regarded as an
ancient marker of East-Asian origin4, 5, has been found at high frequency in
India6 and Ethiopia7, raising the question of its origin. (A haplogroup is a
group of haplotypes that share some sequence variations.) Its variation and
geographical distribution suggest that Asian haplogroup M separated from
eastern-African haplogroup M more than 50,000 years ago. Two other variants
(489C and 10873C) also support a single origin of haplogroup M in Africa. These
findings, together with the virtual absence of haplogroup M in the Levant and
its high frequency in the South-Arabian peninsula, render M the first genetic
indicator for the hypothesized exit route from Africa through eastern
Africa/western India. This was possibly the only successful early dispersal
event of modern humans out of Africa.
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