Transferrin Variants as Markers of Migrations and Admixture between Populations in the Baltic Sea Region
L. Beckmana, C. Sikströma,b, A.-V. Mikelsaarc, A. Kruminad, D. Ambrasienee, V. Kuccaroninskase, G. Beckmana

a Department of Medical Genetics and
b Department of Clinical Microbiology, Umeå University, Sweden;
c Institute of General and Molecular Pathology, University of Tartu, Estonia;
d Department of Medical Biology and Genetics, Medical Academy of Latvia, Riga, Latvia;
e Center of Human Genetics, University of Vilnius, Lithuania

Human Heredity 1998;48:185-191 (DOI: 10.1159/000022800)

Abstract

Transferrin (TF) types were examined by isoelectric focusing in an attempt to elucidate migrations and admixture between populations in the Baltic Sea region. A highly significant heterogeneity between populations was found with respect to TF*C subtypes as well as the rare TF variants B2, B0-1 and DCHI. With the exception for Estonia, increased frequencies of the TF*C3 allele were observed east of the Baltic Sea. The island of Gotland in the middle of the Baltic Sea also showed a high TF*C3 frequency indicating an eastern influence. The TF*DCHI allele, a marker of eastern (Finno-Ugric) influence, was found in Finland and Estonia and on the island of Gotland, but not in mainland Sweden and in the Baltic peoples (Latvians and Lithuanians). These results indicate the presence of a Finno-Ugric, most likely Estonian or Livonian, genetic influence in the Gotland population.

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