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Thread: Genetic Markers of Human Evolution Are Enriched in Schizophrenia

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    Genetic Markers of Human Evolution Are Enriched in Schizophrenia

    Risk of schizophrenia as a side effect of advantageous gene variants related to the acquisition of human traits, like language and complex cognitive skills after the split with neanderthals. Does this affect whether they had human speech?

    http://www.biologicalpsychiatryjourn...855-0/abstract

    Background

    Why schizophrenia has accompanied humans throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for humans’ language, creative thinking, and cognitive abilities.

    Methods

    We analyzed recent large genome-wide association studies of schizophrenia and a range of other human phenotypes (anthropometric measures, cardiovascular disease risk factors, immune-mediated diseases) using a statistical framework that draws on polygenic architecture and ancillary information on genetic variants. We used information from the evolutionary proxy measure called the Neanderthal selective sweep (NSS) score.

    Results

    Gene loci associated with schizophrenia are significantly (p = 7.30 × 10−9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development.

    Conclusions

    Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.

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    Here is an article saying schizophrenia emerged after the Neanderthal-sapiens split.




    http://www.sci-news.com/genetics/sch...als-04102.html




    Schizophrenia – a chronic and serious mental disorder that affects how a person thinks, feels, and acts – poses an evolutionary enigma.

    The disorder has existed throughout recorded human history and persists despite its severe effects on thought and behavior, and its reduced rates of producing offspring.

    “Some scientists think that schizophrenia could be a ‘side effect’ of advantageous gene variants related to the acquisition of human traits, like language and complex cognitive skills, that might have increased our propensity to developing psychoses,” Dr. Andreassen said.

    Dr. Andreassen and his colleagues from Norway, the United States, Denmark and the UK looked to the genome of Neanderthals to pinpoint specific regions of the genome that could provide insight on the origin of schizophrenia in evolutionary history.

    They analyzed genetic data from recent genome-wide association studies of people with schizophrenia for overlap with Neanderthal genomic information.

    “We analyzed recent large genome-wide association studies of schizophrenia and a range of other human phenotypes (anthropometric measures, cardiovascular disease risk factors, immune-mediated diseases) using a statistical framework that draws on polygenic architecture and ancillary information on genetic variants,” they explained.

    “We used information from the evolutionary proxy measure called the Neanderthal selective sweep score.”

    The analysis tells scientists the likelihood that specific regions of the genome underwent positive selection sometime after the divergence of anatomically modern humans and Neanderthals.

    Regions of the human genome associated with schizophrenia, known as risk loci, were more likely to be found in regions that diverge from the Neanderthal genome.

    An additional analysis to pinpoint loci associated with evolutionary markers suggests that several gene variants that have undergone positive selection are related to cognitive processes.

    Other such gene loci are known to be associated with schizophrenia and have previously been considered for a causal role in the disorder.

    The findings were published in the August 15, 2016 issue of the journal Biological Psychiatry.

    “Our findings suggest that schizophrenia vulnerability rose after the divergence of modern humans from Neanderthals and thus support the hypothesis that schizophrenia is a by-product of the complex evolution of the human brain,” Dr. Andreassen said.

    “This study suggests that schizophrenia is a modern development, one that emerged after humans diverged from Neanderthals. It suggests that early hominids did not have this disorder,” said Dr. John H. Krystal, Editor of Biological Psychiatry.

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