Results 1 to 2 of 2

Thread: Detection of Human Adaptation During the Past 2,000 Years

  1. #1
    Senior Member
    Englisc's Avatar
    Join Date
    Apr 2016
    Last Online
    Friday, October 14th, 2016 @ 12:01 PM
    Ethnicity
    English
    Ancestry
    Anglo-Celt
    Subrace
    Atlantid
    Country
    England England
    State
    Yorkshire Yorkshire
    Location
    West Riding
    Gender
    Family
    Youth
    Occupation
    Law student
    Politics
    Conservative, Nationalist
    Religion
    Lapsed Catholic
    Posts
    446
    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    12
    Thanked in
    11 Posts

    Detection of Human Adaptation During the Past 2,000 Years

    Detection of recent natural selection is a challenging problem in population genetics, as standard methods generally integrate over long timescales. Here we introduce the Singleton Density Score (SDS), a powerful measure to infer very recent changes in allele frequencies from contemporary genome sequences. When applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past 2,000 years. We see strong signals of selection at lactase and HLA, and in favor of blond hair and blue eyes. Turning to signals of polygenic adaptation we find, remarkably, that recent selection for increased height has driven allele frequency shifts across most of the genome. Moreover, we report suggestive new evidence for polygenic shifts affecting many other complex traits. Our results suggest that polygenic adaptation has played a pervasive role in shaping genotypic and phenotypic variation in modern humans.
    http://biorxiv.org/content/early/2016/05/07/052084

    Translation: Among Britons, selection for lactose tolerance, height, blue eyes and blond hair.

  2. #2
    Senior Member

    Join Date
    Apr 2016
    Last Online
    Friday, October 7th, 2016 @ 02:13 AM
    Ethnicity
    Anglo-American
    Country
    Other Other
    State
    Cape Province Cape Province
    Gender
    Family
    Youth
    Religion
    none
    Posts
    974
    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    23
    Thanked in
    21 Posts
    HLA is the Human Leukocyte Antigen system (white blood cells) dealing with immunity.

    https://en.wikipedia.org/wiki/Human_leukocyte_antigen

    The significance here FOR US is there are many of these alleles. In modern people of East Asia and Australia, four alleles come from the Denisovans and are in great demand as they have risen to high frequency there.

    Some come from our African ancestors, how many I do not know.

    But four HLA alleles come from Neanderthals and are wide spread in Europe and Western Asia.

    The African HLA system was at a disadvantage outside of Africa and so we introgressed foreign HLA alleles in order to survive.

Similar Threads

  1. Replies: 16
    Last Post: Sunday, October 2nd, 2016, 02:05 AM
  2. 100,000 Years of Human Migration
    By Hersir in forum Anthropogeny & Ethnogenesis
    Replies: 1
    Last Post: Monday, December 27th, 2010, 05:56 AM
  3. Earliest Modern Human European Site, 45,000 years old
    By Dr. Solar Wolff in forum Paleoanthropology
    Replies: 0
    Last Post: Sunday, February 25th, 2007, 04:53 AM
  4. Replies: 1
    Last Post: Saturday, January 27th, 2007, 08:10 PM
  5. Fossils push human emergence back to 195,000 years ago
    By Bismark in forum Paleoanthropology
    Replies: 2
    Last Post: Wednesday, March 16th, 2005, 04:57 PM

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •