Hum Immunol. 2000 Sep;61(9):930-6.

HLA-DRB1 and DQB1 polymorphisms in southern France and genetic relationships with other Mediterranean populations.

Gibert M, Reviron D, Mercier P, Chiaroni J, Boetsch G.

UMR 6578 Adaptabilite Humaine, Biologie et Culture (CNRS/Universite de la Mediterranee) Faculte de Medecine, Marseille, France.

This study presents the results of HLA-DRB1 and DQB1 sequence-specific oligonucleotide probe (SSOP) typing for a population sample of 181 individuals originating from southern France. On the basis of allele and haplotype frequencies, we compared our population with others from the Mediterranean area. Allele frequencies are comparable to those found in other western European populations (France, Portugal, Spain) and indicate neighboring exchanges. The haplotype frequencies showed relationships with North Africans and Jewish populations, as well as the common origin of Moroccan and Lebanese Jews. Therefore, allele frequencies seem to be more able to show recent exchanges while haplotype frequencies might show ancestral relationships. These results may serve as references for future studies of HLA and disease in southern France.