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Thread: Mitochondrial DNA and IQ in Europe

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    You are not wrong, who deem / That my days have been a dream Johannes de León's Avatar
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    Post Mitochondrial DNA and IQ in Europe

    Recently a mitochondrial DNA polymorphism (EST00083) was found at significantly different frequencies in high IQ and low IQ groups in two independent studies. We have used mitochondrial sequences from a range of populations to show that this polymorphism occurred more than once in human history. Furthermore, the polymorphism is particularly common in Europe where it is predominantly associated with a single mitochondrial line (lineage) that appears to date back to the expansion of anatomically modern humans into Europe about 35,000 years ago. Examination of the genetic diversity within this mitochondrial lineage, together with the known migration and settlement of Europeans into the USA, suggests that the observed IQ associated polymorphism found in Cleveland Ohio is likely to be restricted to only one form (sub-group) of this mitochondrial lineage.
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    Post Re: Mitochondrial DNA and IQ in Europe

    The presence of a MspI- mutation has been previously demonstrated in Caucasian (Johnson, Wallace, Ferris, Rattazzi, & Cavalli-Sforza, 1983; Santachiara Benerecetti, Scozzari, Semino, Torroni, Brega, & Wallace, 1988; Benedictis, Rose, Passarino, & Quagliariello, 1989; Semino, Torroni, Scozzari, Brega, & Santachiara Benerecetti, 1991) and Oriental (Johnson et al., 1983; Semino et al., 1991) populations but MspI- has not been found in a sub-Saharan African sample (Johnson et al., 1983).

    Others have postulated that Africans never developed the high IQ mutation, hence their noncivilization.

    Considering the central role that mtDNA gene products play in the energy metabolism of the cell, a causative link between mtDNA mutations and cognitive ability remains a strong possibility. Apart from the existence of a number of neuro-degenerative diseases associated with mtDNA lesions (Wallace, 1992; Shoffner & Wallace, 1994), there is a case in which a patient's IQ was found to increase by 20 points upon treatment for mitochondrial dysfunction (Anezaki, Yanagisawa, Ibayashi, & Miyatake, 1992).

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