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Thread: Molecular diversity of the HLA-A*19 group of alleles in North Indians

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    Post Molecular diversity of the HLA-A*19 group of alleles in North Indians

    Tissue Antigens. 2002 Jun;59(6):487-91.


    Molecular diversity of the HLA-A*19 group of alleles in North Indians: possible oriental influence.

    Jaini R, Naruse T, Kanga U, Kikkawa E, Kaur G, Inoko H, Mehra NK.

    All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

    The present study aims to determine the genetic diversity of the HLA-A19 allelic family in the North Indian and Japanese populations. The HLA-A*19 group of alleles occurred at similar frequencies in North Indians and Japanese as in Caucasians. All the known serological splits of HLA-A19 were observed among the North Indians, i.e. A*33 (15.6%), A*32 (8.6%), A*31 (3.5%), A*30 (3%), A*29 (1.2%) and A*74 (0.77%), while only A*30 (0.7%), A*31 (17.6%) and A*33 (11.7%) were observed in the Japanese. High resolution analysis indicated that the A*29, A*30, A*31 and A*32 alleles were represented by only single subtypes among the North Indians while the HLA-A*33 group comprised two alleles, A*3301 (4.3%) and A*3303 (43.7%). All 15 of the HLA-A*33 positive samples from the Tamil population of South India were found to be A*3303. One novel subtype of A*33, A*3306 was also observed in the North Indian sample. Conversely, only one subtype each of A*30, A*31 and A*33 was encountered in the Japanese population, of which A*3101 and A*3303 were the most frequent (58.5% and 39%, respectively, among the HLA-A*19 group of alleles). All other subtypes of A19 were not found in the Japanese in the present study. The study suggests a significant amount of genetic admixture in the North Indian gene pool from other racial groups, with profound oriental influence.

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    Post Re: Molecular diversity of the HLA-A*19 group of alleles in North Indians

    A*3201, the only allelic subtype of A*32 in this population, seems
    to originate in white populations as this allele was absent among
    the Oriental people.
    I just looked at the graphic and thought this type made the difference. Interesting that East Asian might be present at a significant level, at least according to the conclusions of the study.

    I do not really wonder because though the North Indians are pred. Europid-Caucasoid, North of this region strong Mongolid admixture (Nepal) is present and is reaching in the regions South of Nepal for sure too.

    There were old anthropological ideas that the Tibetan and Japanese-Korean type were related to each other if its about certain features and probably even genetically.
    If looking at this study this might be at least possible...is there such a comparison? I'm just interested.

    Furthermore A*3201 might be an "Aryan marker"? It is said to be more or less typical European.

    Are their exact charts or relations to other genetical features/studies of A*3201?

    Though I'm somewhat sceptical if its about using such markers for racial-ethnic relations without caution.

    Could they be DIRECTLY under selective pressure? Are there articles about such problems if they are neutral markers or can be selected for?
    Last edited by Agrippa; Thursday, June 24th, 2004 at 02:21 AM.
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