Tissue Antigens
Volume 57 Issue 4 Page 308 - April 2001

HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans
Authors' affiliations:A. Arnaiz-Villena1*, M. Karin2*, N. Bendikuze3, E. Gomez-Casado1, J. Moscoso1, C. Silvera1, F.S. Oguz2, A. Sarper Diler2, A. de Pacho1, L. Allende1, J. Guillen1, J. Martinez Laso1
Abstract: Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor-joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians, Jews, Lebanese and other (Eastern and Western) Mediterranean groups seem to share a common ancestry: the older "Mediterranean" substratum. No sign of the postulated Indo-European (Aryan) invasion (1200 B.C.) is detected by our genetic analysis. It is concluded that this invasion, if occurred, had a relatively few invaders in comparison to the already settled populations, i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present-day Kurdish, Armenian and Turkish populations.