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Thread: Redheads: (MC1R) gene on human pigmentation

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    Redheads: (MC1R) gene on human pigmentation

    Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation.

    Flanagan N, Healy E, Ray A, Philips S, Todd C, Jackson IJ, Birch-Machin MA, Rees JL.

    Department of Dermatology, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

    Variants of the melanocortin 1 receptor (MC1R) gene are common in individuals with red hair and fair skin, but the relative contribution to these pigmentary traits in heterozygotes, homozygotes and compound heterozygotes for variants at this locus from the multiple alleles present in Caucasian populations is unclear. We have investigated 174 individuals from 11 large kindreds with a preponderance of red hair and an additional 99 unrelated redheads, for MC1R variants and have confirmed that red hair is usually inherited as a recessive characteristic with the R151C, R160W, D294H, R142H, 86insA and 537insC alleles at this locus. The V60L variant, which is common in the population may act as a partially penetrant recessive allele. These individuals plus 167 randomly ascertained Caucasians demonstrate that heterozygotes for two alleles, R151C and 537insC, have a significantly elevated risk of red hair. The shade of red hair frequently differs in heterozygotes from that in homozygotes/compound heterozygotes and there is also evidence for a heterozygote effect on beard hair colour, skin type and freckling. The data provide evidence for a dosage effect of MC1R variants on hair as well as skin colour.

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    Post Re: Redheads

    Is there an English translation... ?

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    Post Re: Redheads

    I was going to copy and paste some excerpts but it's encrypted.

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    Post Re: Redheads

    The pedigree data provided by the families give further support to the inheritance of red hair as a recessive trait. One family may provide an exception. Family F9 is unusual in that two red-haired parents produced eight children, four of whom have red hair and four do not. The sequence of the MC1R gene from individuals in this family reveals that the father (deceased) can be inferred to be heterozygous for 537InsC with wild-type. His half-sister has the same MC1R genotype and, although elderly and grey when examined, her niece supported her description of red hair when younger. Each of the four red-haired children has inherited 537InsC, in two cases as compound heterozygote with V60L and in two cases with D84E. The four non-red children who inherited the wild-type MC1R have it opposite either V60L or D84E; this indicates that this allele is probably truly wild-type and does not harbour undetected deleterious changes. It thus appears that in this family 537InsC is acting as a dominant allele.

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    Post Re: Redheads

    Quote Originally Posted by Sigrun Christianson
    Is there an English translation... ?
    According to this study I think you'd be classified as a pure red.

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    Post Re: Redheads

    Okay, okay, but is there a difference between the light reds and the dark reds? There are plenty of people who, to my eyes, are dark red (like auburn) or who have red hair, but dark reddish or brown eyebrows and body hair. There are those (like me) who have red hair, but blonde eyebrows and body hair. What's the difference?

    There isn't a single redhead on my maternal side that I can find, unless you count my uncles beards which usually look light red when grown out. My hair comes from my paternal side - all blondes or redheads.

    Anyway, I have also noticed that redheads with my coloration seem to get lighter with age when most people seem to get darker.

    I love the 'redheads need more pain killers' theory.. haha... more drugs for me!

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    Post Re: Redheads

    Quote Originally Posted by Sigrun Christianson
    Okay, okay, but is there a difference between the light reds and the dark reds? There are plenty of people who, to my eyes, are dark red (like auburn) or who have red hair, but dark reddish or brown eyebrows and body hair. There are those (like me) who have red hair, but blonde eyebrows and body hair. What's the difference?



    Anyway, I have also noticed that redheads with my coloration seem to get lighter with age when most people seem to get darker.

    I love the 'redheads need more pain killers' theory.. haha... more drugs for me!
    We must have been separated at birth Sigrun, I have blonde eyebrows and lashes as well. You share my great-grandmother's last name. :carrot

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    Post Re: Redheads

    If I didn't have my coloration, I'd be pissed off and jealous. We rule.

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    Post Re: Redheads

    Quote Originally Posted by Sigrun Christianson
    Okay, okay, but is there a difference between the light reds and the dark reds? There are plenty of people who, to my eyes, are dark red (like auburn) or who have red hair, but dark reddish or brown eyebrows and body hair. There are those (like me) who have red hair, but blonde eyebrows and body hair. What's the difference?
    In this study they divided them into three groups: auburn (reddish brunette), strawberry blond (blond and slightly rufous), and pure red (the red is more intense). I think you're pure red. From what Legs says about herself, she must be too.

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    Post Re: Redheads

    Anyway, I have also noticed that redheads with my coloration seem to get lighter with age when most people seem to get darker.

    I love the 'redheads need more pain killers' theory.. haha... more drugs for me! [/QUOTE]
    I am definatly fading out...my hair is nowhere near the color it used to be.

    It's true! Most of us do need more pain killers and knock-out drugs.
    My last trip to the dentist took 14 shots of Novacane.

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