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Thread: Nandrolone Decanoate Effect in Limbic Regions

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    Post Nandrolone Decanoate Effect in Limbic Regions

    European Journal of Neuroscience
    Volume 15 Issue 3 Page 539 - February 2002
    doi:10.1046/j.0953-816x.2001.01877.x


    The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain
    Pia Johansson-Steensland,1 Fred Nyberg1 and Loris Chahl2

    Abstract

    The increased abuse of anabolic androgenic steroids is a major concern because of physiological and psychological side-effects. In some individuals they induce dramatic behavioural changes such as increased aggression, anxiety and depression. The mechanisms behind these behavioural changes are still poorly understood. In order to obtain information on the brain regions affected by anabolic androgenic steroids, the distribution of neurons containing c-Fos, the protein product of the immediate early gene c-fos, and Fos-related antigens was studied following chronic treatment of guinea-pigs with a high dose of nandrolone decanoate (15 mg/kg i.m. daily for 14 days). The behaviour of the guinea-pigs was monitored for 1 h each day. Animals treated with nandrolone exhibited a significantly greater incidence of biting behaviour during the 14 day treatment period than vehicle-treated animals. A significantly greater density of c-Fos and Fos-related antigen-positive neurons was found in the central nucleus of the amygdala, and of Fos-related antigen-positive neurons in the frontal cortex, the shell of the nucleus accumbens and the supraoptic nucleus in nandrolone-treated animals than in vehicle controls. Therefore, nandrolone induced Fos in brain regions involved in stress, behavioural responses and reward. The increased Fos expression in these limbic brain regions is of particular interest in relation to the behavioural changes reported in humans who abuse anabolic androgenic steroids and the abuse potential of these drugs.

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    Post Nandrolone decanoate affects the density of dopamine receptors

    European Journal of Neuroscience
    Volume 13 Issue 2 Page 291 - January 2001
    doi:10.1046/j.0953-816X.2000.01402.x


    The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain
    Anna M. S. Kindlundh, Jonas Lindblom,1 Lena Bergström,1 Jarl E. S. Wikberg1 and Fred Nyberg

    Abstract

    In recent years a male group of anabolic-androgenic steroid misusers has been identified to share socio-demographic and personality related background factors with misusers of psychotropic substances, as well as being involved in habits of multiple drug use. The present study aimed to assess whether anabolic-androgenic steroids (AAS) would affect the density of the dopamine receptors in areas implicated in reward and behaviour in the male rat brain. The effects of 2 weeks of treatment with i.m. injections of nandrolone decanoate (15 mg/kg/day) on the expression of the D1-like and D2-like receptors were evaluated by autoradiography. Specific binding of D1-like receptors was significantly down regulated in the caudate putamen, the nucleus accumbens core and shell. D2-like receptor densities were down regulated in the nucleus accumbens shell, but up regulated in the caudate putamen, the nucleus accumbens core and the ventral tegmental area. These results are compatible with nandrolone induced neuroadaptive alterations in dopamine circuits associated with motor functions and behavioural paradigms known to be affected following AAS misuse.

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