View Full Version : Genetic Approaches to Understanding Human Adaptation to High Altitude in the Andes

Saturday, April 10th, 2004, 10:37 AM
By J. L. Rupert1,* and P. W. Hochachka, Department of Pathology and Laboratory Medicine and 2Department of Zoology, The University of British Columbia, Vancouver, Canada V6T 2B5


Despite the initial discomfort often experienced by visitors to high altitude, humans have occupied the Andean altiplano for more than 10 000 years, and millions of people, indigenous and otherwise, currently live on these plains, high in the mountains of South America, at altitudes exceeding 3000 m. While, to some extent, acclimatisation can accommodate the one-third decrease in oxygen availability, having been born and raised at altitude appears to confer a substantial advantage in highaltitude performance compared with having been born and raised at sea level. A number of characteristics have been postulated to contribute to a high-altitude Andean phenotype; however, the relative contributions of developmental adaptation (within the individual) and genetic adaptation (within the population of which the individual is part) to the acquisition of this phenotype have yet to be resolved.

A complex trait is influenced by multiple genetic and environmental factors and, in humans, it is inherently very difficult to determine what proportion of the trait is dictated by an individual’s genetic heritage and what proportion develops in response to the environment in which the person is born and raised. Looking for changes in putative adaptations in vertically migrant populations, determining the heritability of putative adaptive traits and genetic association analyses have all been used to evaluate the relative contributions of nurture and nature to the Andean phenotype. As the evidence for a genetic contribution to high-altitude adaptation in humans has been the subject of several recent reviews, this article
instead focuses on the methodology that has been employed to isolate the effects of ‘nature’ from those of ‘nurture’ on the acquisition of the high-altitude phenotype in Andean natives (Quechua and Aymara). The principles and assumptions underlying the various approaches, as well as some of the inherent strengths and weaknesses of each, are briefly discussed.

Dr. Solar Wolff
Sunday, April 18th, 2004, 12:41 AM
Racial differences in high-altitude adaptation are quite interesting. Negros in Denver, Colorado, at 5200 ft. were said to have more trouble delivering children than whites. I have seen Andean athletes and they are able to function quite well at sea level in sports. I would not say that their increased lung capacity made them superior endurance athletes since there are so many other factors involved but it didn't hurt them. Whites seem to be neutral in this. They seem to be able to take altitude after some aclimatization. Sometimes they get altitude sickness if they come up from the lowlands and push themselves too hard all at once. But, if they spend a little time at altitude, or are born at altitude, they do well.