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Tryggvi
Monday, November 15th, 2004, 07:36 AM
Genetic mutation
turns tot into superboy

4-year-old is first documented
human case, scientists say



http://forums.skadi.net/attachment.php?attachmentid=26024&stc=1
A German boy, seen here at
seven-months old, has a genetic
mutation that boosts muscle growth.


The Associated Press

Updated: 12:35 p.m. ET June 24, 2004


BOSTON - Somewhere in Germany is a baby Superman, born in Berlin with bulging arm and leg muscles. Not yet 5, he can hold seven-pound weights with arms extended, something many adults cannot do. He has muscles twice the size of other kids his age and half their body fat.

The discovery, reported in Thursday’s New England Journal of Medicine, represents the first documented human case of such a mutation.

Many scientists believe the find could eventually lead to drugs for treating people with muscular dystrophy and other muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it like steroids to bulk up.

The boy’s mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Baltimore created buff “mighty mice” by “turning off” the gene that directs cells to produce myostatin.


‘Now we can say that myostatin acts the same way in humans
as in animals. We can apply that knowledge to humans,
including trial therapies for muscular dystrophy.’
— Dr. Marcus Schuelke
Charite/University Medical Center Berlin

“Now we can say that myostatin acts the same way in humans as in animals,” said the boy’s physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/University Medical Center Berlin. “We can apply that knowledge to humans, including trial therapies for muscular dystrophy.”

Given the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and activity of myostatin in the body. Wyeth has just begun human tests of a genetically engineered antibody designed to neutralize myostatin.

Dr. Lou Kunkel, director of the genomics program at Boston Children’s Hospital and professor of pediatrics and genetics at Harvard Medical School, said success is possible within several years.

“Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk,” said Kunkel, who is among the doctors participating in the Wyeth research.

Slow wasting process
Muscular dystrophy is the world’s most common genetic disease. There is no cure and the most common form, Duchenne’s, usually kills before adulthood. The few treatments being tried to slow its progression have serious side effects.

Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS.

“If you could find a way to block myostatin activity, you might slow the wasting process,” said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the “mighty mice.”

Lee said he believes a myostatin blocker also could suppress fat accumulation and thus thwart the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth.

Dr. Eric Hoffman, director of Children’s National Medical Center’s Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles.

He said a mystotatin-blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb.

Eventual health problems?
Researchers would not disclose the German boy’s identity but said he was born to a somewhat muscular mother, a 24-year-old former professional sprinter. Her brother and three other close male relatives all were unusually strong, with one of them a construction worker able to unload heavy curbstones by hand.

In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people.

The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems.

In the past few years, scientists have seen great potential in myostatin-blocking strategies.

Internet marketers have been hawking “myostatin-blocking” supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous.

Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

[Source (http://msnbc.msn.com/id/5278028/)]

Stríbog
Monday, November 15th, 2004, 07:43 AM
There have already been many cattle identified with this MyoD mutation.

http://www.t-nation.com/img/photos/195bbpic.jpg

http://www.fitnesspont.hu/mass-shop/picture_gallery/_not_gallery_pix/myostatin_003.jpg

http://www.mad-cow.org/~tom/bull_mutant.gif

In fact, they are their own breed now, called the Belgian Blue.

Tryggvi
Monday, November 15th, 2004, 07:52 AM
There have already been many cattle identified with this MyoD mutation.

http://www.t-nation.com/img/photos/195bbpic.jpg

http://www.fitnesspont.hu/mass-shop/picture_gallery/_not_gallery_pix/myostatin_003.jpg

http://www.mad-cow.org/~tom/bull_mutant.gif

In fact, they are their own breed now, called the Belgian Blue.
Holy Cow! I see a Mr. Universe in the growing. :D

Rey
Monday, November 15th, 2004, 08:02 AM
There's this kid, too. This kind of muscle development at this age can't be just from working out. There's something genetic at work here.

http://www.richardsandrak.com/Pictures.htm

Stríbog
Monday, November 15th, 2004, 08:12 AM
Holy Cow! I see a Mr. Universe in the growing. :D

I see the biggest cuts of prime rib, ribeye and filet mignon imaginable. :D

http://www.ettline.com/beefcuts/img024.jpg

Scoob
Tuesday, November 16th, 2004, 06:07 AM
It is only a matter of time before someone exploits the market demand for this kind of mutation. It could be useful for vanity reasons (many parents would want a son the size of Arnold Schwartzenegger) and economical - corporations could pay employees to have this mutation introduced to their offspring in exchange for paid schooling or something similar.

Dr. Solar Wolff
Tuesday, November 16th, 2004, 06:08 AM
Myostatin was discussed in a recent Scientific American article on strength, doping and the future athelete. Maybe this is not a new mutation. Maybe this is a recessive Neandertal allele.

Stríbog
Tuesday, November 16th, 2004, 06:14 AM
Myostatin was discussed in a recent Scientific American article on strength, doping and the future athelete. Maybe this is not a new mutation. Maybe this is a recessive Neandertal allele.

It's unlikely that if it were merely a recessive allele it would have gone so long before resurfacing.

Marius
Tuesday, November 16th, 2004, 09:41 AM
Are you sure it has something to do with the nationality of the kid?

Gil
Thursday, November 18th, 2004, 09:22 PM
I pity the boys, both of them. It's a disease, not an "augmentation" or a benefic mutation. Saying otherwise is like stating that Huntington's Disease is a good thing.

Cheerio