View Full Version : The HLA genetic constitution of the Bushmen (San)

Monday, June 7th, 2004, 03:48 PM
Hum Immunol. 1990 Aug;28(4):406-15. Related Articles, Links

The HLA genetic constitution of the Bushmen (San).

du Toit ED, Taljaard DG, Marshall J, Ritchie C, Oudshoorn M.

Provincial Laboratory for Tissue Immunology, Cape Town, South Africa.

The HLA-A, -B, and -C antigens of 290 and the DR antigens of 212 !Kung San individuals were characterized. The most frequent antigens were HLA-A30 [gene frequency (gf) = 0.193], Bw58 (gf = 0.303), Cw6 (gf = 0.327), DR4 (gf = 0.273), and DQw3 (gf = 0.553). An unexpected finding was the low frequency of the classic African black antigen Bw42 (gf = 0.004). Marked differences as well as similarities in HLA gene frequencies were observed between the San and the South African Negroes, supporting the view that they had a common origin and were then separated for a very long time. During this period differences developed as a result of selective advantage in the Negroes following the pastoralist-agriculturalist way of life as opposed to the hunter-gatherer way of life. The picture is further complicated by the fact that gene flow, mostly from the San to the southern African Negroes, took place when they met again a few hundred years ago. The data also illustrate HLA haplotypes, linkage disequilibria, and four-locus haplotypes not previously seen in other human populations. The most frequent four-locus haplotype in the San, HLA-Aw43,Cw7,B7,DRw6 was also different from A30, Cw2,Bw42,DR3, the most common among the South African Negroes

Monday, June 7th, 2004, 06:44 PM
Very interesting that San and Bantu had a common origin, then diverged: San lived as hunter-gatherers, and Bantu were agriculturalists/pastoralists.

Interesting that all over the world, hunter-gatherers have facial "looks" that are somewhat similar: UP Europeans (compared to Med), San (compared to Bantu), Ainu (compared to Sinids), etc.