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Euclides
Friday, April 23rd, 2004, 10:51 PM
High-resolution Y chromosome haplotypes of Israeli and Palestinian Arabs reveal geographic substructure and substantial overlap with haplotypes of Jews


Almut Nebel, Dvora Filon, Deborah Weiss, Michael Weale, Marina Faerman, Ariella Oppenheim, Mark Thomas

A1 Department of Hematology, Hebrew University, Hadassah Medical School and Hadassah University Hospital, Jerusalem 91120, Israel
A2 Department of Anthropology, University of California, Davis, USA
A3 Department of Biology, University College London, London, UK
A4 Laboratory of Biological Anthropology and Ancient DNA, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel


Abstract:


Abstract. High-resolution Y chromosome haplotype analysis was performed in 143 paternally unrelated Israeli and Palestinian Moslem Arabs (I&P Arabs) by screening for 11 binary polymorphisms and six microsatellite loci. Two frequent haplotypes were found among the 83 detected: the modal haplotype of the I&P Arabs (~14%) was spread throughout the region, while its one-step microsatellite neighbor, the modal haplotype of the Galilee sample (~8%), was mainly restricted to the north. Geographic substructuring within the Arabs was observed in the highlands of Samaria and Judea. Y chromosome variation in the I&P Arabs was compared to that of Ashkenazi and Sephardic Jews, and to that of North Welsh individuals. At the haplogroup level, defined by the binary polymorphisms only, the Y chromosome distribution in Arabs and Jews was similar but not identical. At the haplotype level, determined by both binary and microsatellite markers, a more detailed pattern was observed. Single-step microsatellite networks of Arab and Jewish haplotypes revealed a common pool for a large portion of Y chromosomes, suggesting a relatively recent common ancestry. The two modal haplotypes in the I&P Arabs were closely related to the most frequent haplotype of Jews (the Cohen modal haplotype). However, the I&P Arab clade that includes the two Arab modal haplotypes (and makes up 32% of Arab chromosomes) is found at only very low frequency among Jews, reflecting divergence and/or admixture from other populations.